The first time I used tarot cards in game it was to simulate a Deck of Many Things. In the beginning this went over well. Having the physical prop was too much for them not to dabble. In the 1st Edition DMG there is a guide to using a regular deck of cards. I used the Rider Tarot deck at the time. And I assigned cards as close as I could to the cards identified in the Deck of Many Things. Today you could use WotC DoMT generator or buy an actual Deck of Many Things.
While I was looking at all the cards I put off to the side I would see their design and think of different boons or punishments. I wrote a post years ago called Deck of Many Things and Then Some, it provides an excellent example of what I ended up doing. I made a Deck of Many More Things. Here's an example.
Playing Card: 6 of Spades
Upon the players next journey any random encounters during the journey will not be random. The encounter will occur and GM selects the most difficult creature/situation available on the list. The creature will focus its attack on the character who drew the card.
Note: The GM will have to decide how many encounters the player will need to endure. To activate this card the character should be going someplace that will at least take one day to travel.
With the advancements with virtual table tops these days you could to something like this virtually. Although there is not replacement for the tactile experience.